This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
申请公布号
WO2010014854(A2)
申请公布日期
2010.02.04
申请号
WO2009US52314
申请日期
2009.07.30
申请人
MARKS, JAMES, D.;LOU, JIANLONG;RODRIGUEZ, MARIA CONSUELOS GARCIA;GEREN, ISIN, N.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
MARKS, JAMES, D.;LOU, JIANLONG;RODRIGUEZ, MARIA CONSUELOS GARCIA;GEREN, ISIN, N.