发明名称 |
Preparation of recombinant rotavirus proteins in milk of transgenic non-human mammals |
摘要 |
The present invention relates to a non-human transgenic mammal whose genome comprises: i) a first transgene comprising a mammary gland specific transcriptional control region operably linked to cDNA encoding a rotavirus protein selected from VP2, VP4, VP6 and VP7 and wherein said cDNA comprises a secretion signal sequence; ii) at least a second transgene comprising a mammary gland specific transcriptional control region operably linked to cDNA encoding another said rotavirus protein and wherein said cDNA comprises a secretion signal sequence; and wherein said rotavirus proteins are secreted separately and auto-assembled in milk in rotavirus like particles (VLP) or aggregates of said rotavirus proteins.
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申请公布号 |
US2010028371(A1) |
申请公布日期 |
2010.02.04 |
申请号 |
US20050591538 |
申请日期 |
2005.03.04 |
申请人 |
BIOPROTEIN TECHNOLOGIES |
发明人 |
COHEN JEAN;SOLER ERIC;HOUDEBINE LOUIS-MARC;SCHWARTZ-CORNIL ISABELLE;FOURGEUX CYNTHIA;PAREZ NATHALIE;GARBARG-CHENON ANTOINE;COHEN IVAN;COHEN SERGE |
分类号 |
A61K39/00;A01K67/027;A61K39/15;A61P35/00;A61P37/00;C07K1/00;C07K14/14;C12N7/04;C12N15/85 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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