发明名称 |
GLYCOPROTEINS PRODUCED IN PLANTS AND METHODS OF THEIR USE |
摘要 |
Methods of increasing the yield in plant expression of recombinant proteins comprising: engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.
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申请公布号 |
US2010029548(A1) |
申请公布日期 |
2010.02.04 |
申请号 |
US20080117692 |
申请日期 |
2008.05.08 |
申请人 |
OHIO UNIVERSITY |
发明人 |
KIELISZEWSKI MARCIA J.;XU JIANFENG;KOPCHICK JOHN;OKADA SHIGERU;MEYER GARY D. |
分类号 |
A61K38/14;A61K38/27;A61P3/10;A61P5/00;C07K14/415;C07K14/575;C07K14/61;C07K14/765;C12N15/62;C12N15/82;C12P21/00 |
主分类号 |
A61K38/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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