ACTIVE IMMUNISATION AGAINST GIP

摘要

The present invention provides a composition for active immunisation. The composition comprises an immunogen, being human GIP (SEQ ID NO: 1), or an analogue thereof, coupled by a crosslinker to an antigenicity-conferring carrier protein material; and an immunologically acceptable vehicle. The analogue of human GIP comprises at least 12 amino acid residues from the N-terminal end of SEQ ID NO: 1 and optionally comprises one or more amino acid substitutions or modifications selected from the group consisting of: an amino acid substitution or modification at position 1, an amino acid substitution or modification at position 2, and an amino acid substitution or modification at position 3. Alternatively, the analogue of human GIP comprises SEQ ID NO: 1 and further comprises one or more amino acid substitutions or modifications selected from the group consisting of: an amino acid substitution or modification at position 1, an amino acid substitution or modification at position 2, and an amino acid substitution or modification at position 3. The invention also provides a method of alleviating or treating diabesity and / or insulin resistance and / or a method of moderating blood glucose excursions. The methods comprise administering the above-mentioned composition to a host animal at regular intervals.