发明名称 |
NEURAL STEM CELL ISOLATES FROM THE DENTAL PAPILLARY ANNULUS OF DEVELOPING TEETH |
摘要 |
<p>Multipotent cranial neural crest stem cells and non-lineage committed precursor cells are described. The neural crest cells are capable of self-renewal, of being cultured into clonal spheroids including neurospheres, and of differentiation into neurons or other neuroepithelial cells. The non- lineage committed precursors are capable of differentiation into neurons, astrocytes and oligodendrocytes, and are capable of de-differentiation into induced pluripotent stem cells (iPSCs). Methods of obtaining, generating, isolating and culturing cranial neural crest stem cells and non- lineage committed precursor cells are also disclosed, including methods of providing a substantially pure in vitro cell culture consisting essentially of stem cells capable of multipotent differentiation and de-differentiation to a pluripotent state, which may be used for medical research or preserved for future therapeutic use by their autologous donor or a heterologous recipient.</p> |
申请公布号 |
WO2010014675(A1) |
申请公布日期 |
2010.02.04 |
申请号 |
WO2009US52058 |
申请日期 |
2009.07.29 |
申请人 |
BIODONTOS, LLC.;GARY, RACEY;BOWERMASTER, RUSSELL;BOB, THOMAS |
发明人 |
GARY, RACEY;BOWERMASTER, RUSSELL;BOB, THOMAS |
分类号 |
C12N5/00 |
主分类号 |
C12N5/00 |
代理机构 |
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代理人 |
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地址 |
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