Chlorpyrimidin-Derivate

摘要

1,247,584. Chloropyrimidine derivatives. FARBENFABRIKEN BAYER A.G. 10 Jan., 1969 [12 Jan., 1968], No. 1670/69. Heading C2C. 2 - Substituted - 4,5,6 - trichloropyrimidine derivatives are prepared by reacting a compound of Formula I in which A is a C 1-6 alkyl radical or a carbocyclic - or heterocyclic - aromatic radical, is a radical which can be split off under the reaction conditions, and n is 1 or 2, with an excess of chlorine at temperatures between 0‹ and 250‹ C. and optionally under U.V. irradiation. The substituent in the 2-position of the resulting pyrimidine is a possibly chlorinated radical A. The process may be carried out in the presence or absence of a chlorination catalyst, e.g. ferric chloride, or an inert diluent or solvent, e.g. a chlorinated aliphatic or aromatic hydrocarbon. The radical may be, for example, methyl, benzyl or pchlorobenzyl. Examples of radicals A are alkyl, phenylene, phenyl, substituted phenyl, naphthyl, tetrahydronaphthyl, pyridyl, furyl and thienyl. In examples, 2-dichloromethyl-, -trichloromethyl-, -pentaohloroethyl-, -phenyl-, - (41 - trichloromethyl) - phenyl) -, - (22 - or 31. chloro - 41 - trichloromethylphenyl) -, - (41- chloromethylphenyl) -, - (trichloro - 1 - naphthyl) - and - (61 - chloro - 2 - pyridyl) - 4,5,6- trichloropyrimidines and 1,4 - bis - (4,5,6 - trichloro - 2 - pyrimidinyl) - benzene are prepared. 3 - (N,N - dibenzylamino) - propionitrile and N,N1 - dimethyl - N,N1 - bis - (# - cyanoethyl)- 1,4 - bis - (aminomethyl) - benzene are prepared by reacting acrylonitrile with dibenzylamine and 1,4-bis-(methylamino-methyl)-benzene respectively.