Process for the synthesis of ezetimibe and intermediates useful therefor

摘要

The present invention discloses novel and useful intermediates for the synthesis of ezetimibe (EZT), which intermediates share a characteristic Z -isomeric structure. Based on Z -5-(4-fluorophenyl)-pent-4-enoic acid, and proceeding the synthesis through further Z- intermediates, a total synthesis is presented to obtained final ezetimibe in high yields.