COMBINED MENINGITIS VACCINE

摘要

A combined vaccine comprising a Haemophilus influenzae type B (Hib) oligosaccharide conjugate and a Neisseria meningitidis serogroup C (MenC) oligosaccharide conjugate. The combination vaccine is free from interference between the antigens used. The vaccine may also include a Neisseria meningitidis serogroup B (MenB) oligosaccharide conjugate. The vaccine may be used in the prophylaxis or treatment of bacterial meningitis and allows economical, safe and expedient vaccination against the prevalent causes of meningitis. Advantageously, carrier priming may be exploited in order to maximize response to the vaccine, for example using a diphtheria, pertussis and tetanus (DTP) vaccine. The oligosaccharides are preferably size-selected and advantageously have a degree of polymerization of 4 or more.