| 摘要 |
PURPOSE: A method for preparing hexahydrocannabinol derivative which is a kind of cannabinoid is provided to ensure high yield of target compound through one-step reaction. CONSTITUTION: A hexahydrocannabinol of general formula II is prepared by reacting aldehyde having unsaturated bond with a compound of general formula I in the presence of non reaction organic solvent under the presence of catalyst. In general formula I, R1 is hydrogen, OH, OCH3, OEt, ether group, alkenyl group; R2 is hydrogen, carbonyl, ester group or alkenyl group; R3 is alkyl group such as hydrogen, methyl, ethyl, and pentanyl or alkenyl group; and R4 is hydrogen, alkyl or alkenyl group. The aldehyde having unsaturated bond citral, citronellal, citronelly oxyacetalde hyde, cyclamen aldehyde, hydroxycitronellal, lilial or bourgeonal.
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