| 发明名称 |
Inhibitors of Akt activity |
| 摘要 |
The present invention is directed to compounds which contain substituted pyridazines and pyrimidines moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
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| 申请公布号 |
US7655649(B2) |
申请公布日期 |
2010.02.02 |
| 申请号 |
US20050547367 |
申请日期 |
2005.04.05 |
| 申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BILODEAU MARK T.;CHUA PETER C.;COSFORD NICHOLAS D. P.;HOFFMAN JACOB M.;NAGASAWA JOHNNY YASUO |
| 分类号 |
C07D401/14;A61K31/501;A61K31/506;A61K31/5377;A61K31/541;A61P35/00;C07D237/08;C07D237/10;C07D239/24;C07D239/28;C07D265/16;C07D279/12;C07D295/00;C07D317/12;C07D401/10;C07D403/00;C07D403/10;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D487/04;C07D498/04;C07F5/04 |
主分类号 |
C07D401/14 |
| 代理机构 |
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