发明名称 |
Crystallized structure of estrogen related receptor gamma in complex with bisphenol A |
摘要 |
A method for the identification of novel compounds that interact and stabilize the ligand binding domain of estrogen-related receptor gamma (ERRgamma), a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands, including Bisphenol A, and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERRgamma are disclosed.
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申请公布号 |
US7655756(B2) |
申请公布日期 |
2010.02.02 |
申请号 |
US20060442004 |
申请日期 |
2006.05.26 |
申请人 |
JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT, LLC |
发明人 |
ABAD MARTA C.;RENTZEPERIS DIONISIOS;O'NEILL JOHN;ASKARI HOSSEIN B.;MILLIGAN CYNTHIA M.;LEWANDOWSKI FRANK A. |
分类号 |
C07K14/00;A61K38/16;C08H1/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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地址 |
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