PROCESS FOR THE SYNTHESIS OF 1,3,4,5-TETRAHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

摘要

PROCESS FOR THE SYNTHESIS OF COMPOUNDS OF FORMULA (1): WHEREIN R1 AND R2, WHICH MAY BE THE SAME OR DIFFERENT, EACH REPRESENT A LINEAR OR BRANCHED (C1-C8)ALKOXY GROUP OR FORM, TOGETHER WITH THE CARBON ATOM CARRYING THEM, A 1,3-DIOXANE, 1,3-DIOXOLANE OR 1,3-DIOXEPANE RING. APPLICATION IN THE SYNTHESIS OF IVABRADINE, ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID AND HYDRATES THEREOF.