Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

摘要

Disclosed is a compound having the formula (I) wherein the substituents are described in the specification. Also disclosed is the use of the compound in a preparation for treating or preventing a metabolic disease, cancer, a cardiovascular disease, a renal disease, an autoimmune disease, macular degeneration, ischemia-reperfusion injury, pain or a pain-related syndrome, disease-related wasting, an asbestos-related condition, central nervous system injury/damage or pulmonary hypertension.