发明名称 |
Hydrochlorides and hydrates of 1-[(3-cyanopyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-aminopiperidin-1-yl)xanthine, their preparation and their use as medicaments |
摘要 |
The disclosure relates to salts of 1-[(3-cyanopyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-aminopiperidin-1-yl]xanthine with hydrochloric acid, and also to their enantiomers, mixtures thereof and hydrates thereof. Particularly disclosed are monohydrochloride and dihydrochloride salts of 1-[(3-cyanopyridin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-aminopiperidin-1-yl]xanthine in crystalline non-hydrate form. Pharmaceutical compositions of these salts are suitable for the treatment of a condition selected from type I and type II diabetes mellitus, arthritis, obesity, allograft transplantation and osteoporosis caused by calcitonin.
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申请公布号 |
NZ566187(A) |
申请公布日期 |
2010.01.29 |
申请号 |
NZ20060566187 |
申请日期 |
2006.07.26 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
PFRENGLE, WALDEMAR;SIEGER, PETER |
分类号 |
C07D473/04;A61K31/522;A61P3/10 |
主分类号 |
C07D473/04 |
代理机构 |
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