| 摘要 |
The disclosure relates to amines and their use as inhibitors of a mammalian anandamide transporter. Particularly disclosed are amines of formula (B), wherein the variables are as defined in the specification. These amine compounds are suitable for the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity. Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. The disclosure also relates to combinatorial libraries of amines, and methods for preparing the libraries. (62) Divided Out of 537225
|
