Sequence selective pyrrole and imidazole polyamide metallocomplexes

摘要

Disclosed is a compound of formula (1) or a salt thereof, wherein M1 and M2 are the same or different and are individually selected from a platinum complex, a palladium complex, a ruthenium complex, and a rhodium complex, wherein at least one of M1 and M2 is capable of interacting with a major groove or minor groove of a polynucleotide, P1 and P2 are the same or different and are each a sequence selective pyrrole-imidazole polyamide wherein each pyrrole-imidazole polyamide (P1, P2) independently comprises a plurality of heterocyclic rings selected from the group consisting of optionally substituted N-methylimidazole (Im), optionally substituted N-methylpyrrole (Py) and optionally substituted 3-hydroxy N-methylpyrrole (Hp) and wherein the rest of the substituents are disclosed within the specification. Also disclosed is a compound of formula (3) wherein the substituents are disclosed within the specification. Also disclosed is the use of the above compounds of formula (1) and formula (3) in the manufacture of a medicament for treating a disease selected from cancer, HIV and Hepatitis C.