1-(2H-PYRAZOL-3-YL)-3-<4-[1-BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL>-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS

摘要

THE PRESENT INVENTION PROVIDES COMPOUNDS OF FORMULA (I) WHEREIN ( ) IS AN OPTIONAL ETHYLENE BRIDGE; R1 IS ALKYL, CYCLOALKYL, ARYL OR ARYL SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM ALKYL, ALKOXY AND AMINO, OR R1 IS PYRIDYL OR PYRIDYL SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM ALKYL, ALKOXY AND AMINO; R2 IS OPTIONALLY SUBSTITUTED ALKYL, ALKOXYALKYL, OPTIONALLY SUBSTITUTED CYCLOALKYLALKYL, ARYLALKYL, OR R2 IS ARYLALKYL SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM ALKYL, ALKOXY; X IS -C(O)-, -C(O)-CH2-, -8(0)2., OR NH-C(O)-; AND A IS OPTIONALLY SUBSTITUTED ALKYL OR OTHER SUBSTITUENTS AS DEFINED IN CLAIM 1. PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS, THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE IN THE TREATMENT OF DISECRE STATES CAPABLE OF BEING MODULATED BY THE INHIBITION OF P38 KINASE AND/OR TUMOR NECROSIS FACTOR (TNF), SUCH AS ASTHMA OR JOINT INFLAMMATION.