Methods and dosage forms for controlled delivery of paliperidone or risperidone

摘要

Disclosed is a dosage form comprising two or more layers, said two or more layers comprising a first layer and a second layer, said first layer comprising paliperidone or a pharmaceutically acceptable salt thereof, and said second layer comprising a polymer and paliperidone or a pharmaceutically acceptable salt thereof; an outer wall surrounding said two or more layers; and an orifice in said outer wall; wherein the ratio of the amount of paliperidone or pharmaceutically acceptable salt thereof in the first layer to the amount of paliperidone or pharmaceutically acceptable salt thereof in the second layer is less than 1.0. (62) Divided Out of 537756