Monovalent antibody fragments useful as therapeutics

摘要

Provided is an antibody fragment comprising a single antigen binding arm and an Fc region that increases stability of said antibody fragment compared to a Fab molecule comprising said antigen binding arm, wherein the Fc region comprises a complex of a first and a second Fc polypeptide, wherein one but not both of the Fc polypeptides is an N-terminally truncated heavy chain, wherein the antibody fragment does not specifically bind a T cell surface antigen. Further provided are corresponding nucleic acids and methods of making the antibodies.