2-carboxyalkoxyaroyl-6-carboxyalkoxyaryl-3 4-dihydro-2h

摘要

2-(carboxy alkoxyaroyl)6-(carboxy-alkoxyaryl)-3,4-dihydro-2H-pyrans, their salts, esters and amides. (I) R = st. or branched chain alkyl-, trifluoromethylalkyl-, aryl-, aryloxy-, arylthioalkyl-, cycloalkyl- R1 = H or deuterium- R2 = phenylene (II):- or naphthalene (III):- where X = same or different H-, hal-, alkyl-, alkoxy-, -CF3 there being at least one H- next to the point of connection between phenylene or naphthalene and the carbonyl gp. or the pyran ring m = 1-2 n = 1-3 particularly 2,5-diethyl 2-(carboxymethoxybenzoyl)-6-(carboxyethoxyphenyl)-3,4-dihydro-2H-- pyran (IV); and 2,5-diethyl 2-(carboxymethoxynaphthoyl)-6-(carboxymethylnaphthyl)-3,4-dihydro- -2H-pyran (V). Inhibition of lactic acid dehydrogenase partic. in tumour cells.