AMINO-BENZIMIDAZOLES DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION

摘要

THE PRESENT INVENTION CONCERNS AMINO-BENZIMIDAZOLES HAVING INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS AND HAVING THE FORMULA THEIR PRO DRUGS, N-OXIDES, ADDITION SALTS, QUATERNARY AMINES, METAL COMPLEXES AND STEREOCHEMICALLY ISOMERIC FORMS WHEREIN Q IS AR1 OR C1-6ALKYL SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM TRIFLUOROMETHYL, C3-7CYCLOALKYL, AR2, HYDROXY, C1-4ALKOXY, C1-4ALKYLTHIO, AR2-OXY-, AR2-THIO-, AR2(CH2)NOXY, AR2(CH2)NTHIO, HYDROXYCARBONYL, AMINO CARBONYL, C1-4ALKYLCARBONYL, AR2CARBONYL, C1-4ALKOXYCARBONYL, AR2(CH2)NCARBONYL, AMINOCARBONYLOXY, C1-4ALKYLCARBONYLOXY, AR2CARBONYLOXY, AR2(CH2)NCARBONYLOXY, HYDROXY-C2-4-ALKYLOXY, C1-4ALKOXYCARBONYL(CH2)NOXY, MONO- OR DI(C1-4ALKYL)-AMINOCARBONYL, MONO- OR DI(C1-4ALKYL)AMINOCARBONYLOXY, AMINOSULFONYL, MONO- OR DI(C1-4ALKYL)AMINOSULFONYL, DIOXOLANYL OPTIONALLY SUBSTITUTED WITH ONE OR TWO CI-6ALKYL RADICALS, AND A HETEROCYCLE SELECTED FROM PYRROLIDINYL, PYRROLYL, DIHYDROPYRROLYL, THIAZOLIDINYL, IMIDAZOLYL, TRIAZOLYL, PIPERIDINYL, HOMOPIPERIDINYL, PIPERAZINYL, PYRIDYL AND TETRAHYDROPYRIDYL, WHICH EACH MAY OPTIONALLY BE SUBSTITUTED WITH OXO OR C1-6ALKYL; G IS A DIRECT BOND OR OPTIONALLY SUBSTITUTED C1-10ALKANEDIYL R1 IS AR1 OR A MONOCYCLIC OR BICYCLIC HETEROCYCLE; ONE OF R2A AND R3A IS C1-6ALKYL AND THE OTHER ONE OF R2A ANDR3A IS HYDROGEN; IN CASE R2A IS DIFFERENT FROM HYDROGEN THEN R2B IS HYDROGEN OR C1-6ALKYL, AND R3B IS HYDROGEN; IN CASE R3A IS DIFFERENT FROM HYDROGEN THEN R3B IS HYDROGEN OR C1-6ALKYL, AND R2B IS HYDROGEN; AR1 IS PHENYL OR SUBSTITUTED PHENYL AND AR2 IS PHENYL OR SUBSTITUTED PHENYL. IT FURTHER CONCERNS THEIR PREPARATION AND COMPOSITIONS COMPRISING THEM, AS WELL AS THEIR USE AS A MEDICINE.