Toll-like receptor 14 (TLR14) and use thereof

摘要

Provided is the use of a polypeptide comprising a fragment or variant of the protein TLR14 (KIAA0644) in the manufacture of a medicament for the treatment of an immune or inflammatory disorder, wherein the fragment comprises at least 12 contiguous amino acids, and the variant comprises an amino acid sequence that is at least 70% identical to the amino acid sequence of the specified sequences. Further provided are methods of identifying compounds with Toll-like receptor activity using the polypeptides or genes encoding the polypeptides.