发明名称 Methods for converting quinolone esters into quinolone amides
摘要 The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a Lewis acid having formula MLn, wherein L is a halogen atom or an organic radical, n is 3-5, and M is a group III elemental atom, a group IV elemental atom, As, Sb, V or Fe, wherein A, B, V, X, Z, W, R1, R2, R5, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8 are substituents. Z4, Z5, Z6, Z7, and Z8 are substituents.
申请公布号 US7652134(B2) 申请公布日期 2010.01.26
申请号 US20050149007 申请日期 2005.06.09
申请人 CYLENE PHARMACEUTICALS, INC. 发明人 WHITTEN JEFFREY P.;PIERRE FABRICE;REGAN COLLIN;SCHWAEBE MICHAEL;YIANNIKOUROS GEORGE PETROS;JUNG MICHAEL
分类号 C07D413/14;C07D401/14 主分类号 C07D413/14
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