发明名称 TETRAZOLE-CONTAINING RAPAMYCIN ANALOGS WITH SHORTENED HALF-LIVES
摘要 A compound having formula (I) or a pharmaceutically acceptable salt or prodrug thereof, is an immunomodulary agent and is useful in the treatment of restenosis and immune and autoimmune diseases. Also, disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosis, post-transplant tissue rejection, and immune and autoimmune disease in a mammal, with minimized side-effects due to shortened half-lives. (see formula I)
申请公布号 CA2303934(C) 申请公布日期 2010.01.26
申请号 CA19982303934 申请日期 1998.09.24
申请人 ABBOTT LABORATORIES 发明人 MOLLISON, KARL W.
分类号 C07D498/18;A61K31/395;A61K31/436;A61P9/00;A61P31/00;A61P31/10;A61P35/00;A61P37/02;A61P37/06;A61P43/00;C07D221/00;C07D273/00;C07D331/00;C07D498/08 主分类号 C07D498/18
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