| 摘要 |
The invention concerns a method for preparing 4'--bromomethyl-biphenyl derivatives of general formula (I) (see formula I) in which R is .cndot. a cyano group .cndot. a group: -CO2R1 or -CONR2R3 in which R1, R2 and R3, which may be identical or different, represent hydrogen or a linear or branched C1-C6 alkyl group which can be optionally substituted with a halogen atom, a hydroxyl, amino, C1-C4 alkoxy group or with 1 to 3 phenyl groups optionally substituted with 1 to 3 groups chosen from halogen atoms and hydroxyl, nitro, C1-C4 alkyl and C1-C4 alkoxy groups, .cndot. a tetrazolyl group of general formula: (see formula III) in which R4, in position 1 or preferably in position 2 of the tetrazolyl group, represents hydrogen or a protecting group, by reacting in a biphasic medium and under the effect of light irradiation, a bromination agent selected among bromine, N-bromoacetamide, N-bromophthalimide, N-bromomaleimide, N-bromosulphonamide, N-bromosuccinimide, 1,3-dibromo-5, 5-dimethylhydantoin and an alkaline metal bromhydric/bromate acid system with a biphenyl derivative of general formula (II) (see formula II) in which R has the same meaning as above, thereby obtaining the desired compound.
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