发明名称 |
METHOD FOR PREPARING MATERIALS HAVING ANTITHROMBOTIC ACTIVITY FROM MUSKRAT MUSK AND MATERIALS OBTAINED FROM THE METHOD |
摘要 |
Disclosed herein is a method of preparing an antithrombotic agent from muskrat musk and an antithrombotic agent having a high potency obtained therefrom, wherein the antithrombotic agent is prepared by treating muskrat musk with ethanol to obtain an ethanol extract; carrying out two normal phase column chromatographies while raising the combination ratio of hexane and ethyl acetate to obtain numerous fractions; carrying out thin layer chromatographies and identifying the material patterns of the fractions with UV lamps and 10% sulfuric acid to divide the materials which have a similar moving distance into groups; measuring a thrombin time of each group to isolate a group having a potent antithrombotic activity; carrying out a reverse phase column chromatography while raising the combination ratio of acetonitrile and water to obtain numerous fractions; and isolating an antithrombotic agent material having a high potency therefrom. According to the present invention which provides an antithrombotic agent having a high potency from muskrat musk, the value added of muskrat musk is raised.
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申请公布号 |
US2010015243(A1) |
申请公布日期 |
2010.01.21 |
申请号 |
US20070519342 |
申请日期 |
2007.12.17 |
申请人 |
KIM KEUN KI;KANG HAN SEOK;CHOI YONG JU;SHIN TEAK SOOKI;KIM SEON KU;LEE JAE HO;KIM YONG GYUN;JEON SANG YOON |
发明人 |
KIM KEUN KI;KANG HAN SEOK;CHOI YONG JU;SHIN TEAK SOOKI;KIM SEON KU;LEE JAE HO;KIM YONG GYUN;JEON SANG YOON |
分类号 |
A61K35/55 |
主分类号 |
A61K35/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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