发明名称 |
Iminopyridine Derivative and Use Thereof |
摘要 |
Provided are an iminopyridine derivative having a selective alpha1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an alpha1D adrenergic receptor antagonistic action. An alpha1D adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an alpha1D adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.
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申请公布号 |
US2010016315(A1) |
申请公布日期 |
2010.01.21 |
申请号 |
US20070446960 |
申请日期 |
2007.10.22 |
申请人 |
YOSHIDA MASATO;SUZAKI TOMOHIKO;KOHARA YASUHISA;KUNO HARUHIKO;NAGABUKURO HIROSHI;SAIKAWA REIKO;OKABE YUUICHI;IMAI SHIGEMITSU |
发明人 |
YOSHIDA MASATO;SUZAKI TOMOHIKO;KOHARA YASUHISA;KUNO HARUHIKO;NAGABUKURO HIROSHI;SAIKAWA REIKO;OKABE YUUICHI;IMAI SHIGEMITSU |
分类号 |
A61K31/5377;A61K31/44;A61P13/02;C07D213/78;C07D413/10;C12Q1/02 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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