发明名称 |
Methods for increasing analgesic potency and attenuating adverse excitatory effects of bimodally-acting opioid agonists by inhibiting GM1-ganglioside |
摘要 |
The present invention provides a method for increasing analgesic potency of a bimodally-acting opioid agonist in a subject, by inhibiting GM1-ganglioside in nociceptive neurons. The present invention further provides a method for treating pain in a subject in need of treatment thereof. Also provided in the present invention is a method for treating chronic pain in a subject in need of treatment thereof. Additionally, the present invention provides a method for treating tolerance to or an addiction to a bimodally-acting opioid agonist in a subject in need of treatment thereof. Finally, the present invention provides a pharmaceutical composition of analgesic agents and a pharmaceutically-acceptable carrier.
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申请公布号 |
US2010015147(A1) |
申请公布日期 |
2010.01.21 |
申请号 |
US20090586518 |
申请日期 |
2009.09.23 |
申请人 |
CRAIN STANLEY M;SHEN KE-FEI |
发明人 |
CRAIN STANLEY M.;SHEN KE-FEI |
分类号 |
A61K39/395;A61K45/06;A61K31/00;A61K31/135;A61K31/137;A61K31/215;A61K31/4465;A61K31/451;A61K31/4748;A61K31/485;A61K33/00;A61K33/04;A61K38/00;A61K38/22;A61K38/33;A61P25/04;A61P25/20;A61P43/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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