| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide another method for more safely producing an 2-aminopyrazine derivative known as a medicine, especially an adenosine antagonist, in shortened total processes and in a higher total yield than those of known methods for producing the derivative; an intermediate thereof; and a method for producing the intermediate. Ž<P>SOLUTION: The inventors have zealously examined another method for producing the 2-aminopyrazine derivative, and has consequently found that a pyrazine ring can safely and efficiently be constructed by reacting a pyridazinone derivative whose adjacent carbon atoms are diketone or its salt with a diaminopropionic acid derivative or its salt, and that the 2-aminopyrazine derivative can efficiently be produced by adopting the pyrazine compound obtained by the reaction or its salt as an intermediate. Thus, the present invention has been completed. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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