发明名称 |
Methods for Producing Polypeptides by Regulating Polypeptide Association |
摘要 |
In the course of the present invention, it was discovered that one could regulate association between polypeptides by modifying amino acid residues that form the interface during the association to amino acids carrying the same type of charge. In this context, the present invention enables efficient formation of heterologous molecules. For example, the present invention can be suitably applied to the preparation of bispecific antibodies.
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申请公布号 |
US2010015133(A1) |
申请公布日期 |
2010.01.21 |
申请号 |
US20060910128 |
申请日期 |
2006.03.31 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA TOMOYUKI;TSUNODA HIROYUKI |
分类号 |
A61K39/395;A61P35/00;C07H21/00;C07K16/18;C12N5/07;C12P21/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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