| 摘要 |
A di(pyrimidine nucleoside 5'-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5'-triphosphate into a pyrimidine nucleoside 5'-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5'-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron. Through the method of the invention, a di(pyrimidine nucleoside 5'-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5'-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5'-)polyphosphate.
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