HTLV-II VECTOR AND METHODS OF USE

摘要

The disclosure provides compositions and methods of use of an HTLV-II viral vector. In embodiments, the disclosure provides an isolated viral vector comprising at least a portion of the HTLV-II genome encoding the gag, pro, and pol genes and lacking all or a portion of the pX region and a polynucleotide encoding all or a portion of a protein that corresponds to a viral protein from a heterologous virus located within the deletion in the pX region. The viral vectors are useful for inducing an immune response to the viral protein form the heterologous virus.