发明名称 |
IMMUNOTHERAPEUTIC METHOD |
摘要 |
<p>The present invention provides a method of monitoring the efficacy of an immunotherapy in a mammalian subject, wherein the subject has been administered an immunotherapy, wherein the immunotherapy comprises a viral vector containing a polynucleotide encoding an antigen, wherein the viral vector is capable of transducing cells in the mammalian subject to cause the cells to express the antigen; the method comprising: (b) measuring, from a biological sample isolated from the subject, an immune response of the subject to the antigen and comparing the immune response of the subject to the antigen to a reference measurement of immune response to the antigen; (c) measuring, from a biological sample isolated from the subject, an immune response of the subject to the viral vector and comparing the immune response of the subject to the viral vector to a reference measurement of immune response to the viral vector; and (d) determining efficacy based on the comparisons of (b) and (c), wherein an elevated immune response to the antigen and a reduced immune response to the viral vector are indicative of an effective immunotherapy.</p> |
申请公布号 |
WO2010007365(A1) |
申请公布日期 |
2010.01.21 |
申请号 |
WO2009GB01748 |
申请日期 |
2009.07.15 |
申请人 |
OXFORD BIOMEDICA (UK) LTD;HARROP, RICHARD;SHINGLER, WILLIAM;MCDONALD, MICHAEL;NAYLOR, STUART |
发明人 |
HARROP, RICHARD;SHINGLER, WILLIAM;MCDONALD, MICHAEL;NAYLOR, STUART |
分类号 |
G01N33/68;A61K39/00;C12N15/863;G01N33/574 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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