| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins. <P>SOLUTION: Nucleic acid molecules encoding the T-bet of mouse, human are isolated. Antisense nucleic acid molecules, recombinant expression vectors, host cells into which the expression vectors have been introduced, and non-human transgenic animals carrying a T-bet-introduced gene are produced. T-bet proteins, T-bet fusion proteins and anti-T-bet antibodies are also produced. As methods for using the T-bet composition, they are used for methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet. <P>COPYRIGHT: (C)2010,JPO&INPIT |
