2-ethylidene-19-nor-vitamin D compounds

摘要

Biologically active 19-nor vitamin D analogs substituted at C-2 in the A-ring with an ethylidene group. These compounds have preferential activity on mobilising calcium from bone and either high or normal intestinal calcium transport activity which allows their <Italic>in vivo</Italic> administration for the treatment of metabolic bone diseases where bone loss is a major concern. These compounds are also characterised by high cell differentiation activity.