METHOD FOR PREDICTION OF CLINICAL EFFECTIVENESS IN CHRONIC PURULENT RHINOSINUSITIS

摘要

FIELD: medicine. ^ SUBSTANCE: invention concerns medicine, namely otorhinolaryngology and can be used for prediction of clinical effectiveness in chronic purulent rhinosinusitis. The method involves prediction of clinical effectiveness in chronic purulent rhinosinusitis provided the recombinant cytokine immunotherapy based on genetic typing of polymorphism of cytokine gene. The therapy includes recombinant interleukine-1, and the presence of low-producing allele cytokine gene IL-1, increased phagocytic activity of neutrophils ensured by higher level IL-8 is predicted with high clinical effectiveness secured. ^ EFFECT: application of the invention allows predicting efficiency of the forthcoming therapy with recombinant interleukine-1 ensured by determination individual susceptibility of each patient considering genotype-based functional activity of cells. ^ 2 cl, 4 dwg, 4 ex