17ß-CYANO-19-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE.

摘要

The 17ß-cyano-19-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula (1), in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO2R, wherein R is hydrogen or C1-C4 alkyl, R¹ and R² independently of one another are hydrogen or methyl, or R¹ and R² together form methylene, or are omitted, whereby a double bond is formed between C¹ and C², R⁴ is hydrogen or halogen and in addition either: R^6a, R^6b together form methylene or 1,2 ethanediyl or R^6a is hydrogen and R^6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R⁷ is selected from the group comprising hydrogen, C1-C4 alkyl, C2-C3 alkenyl and cyclopropyl, or: R^6a is hydrogen and R^6b and R⁷ together form methylene, or are omitted, whereby a double bond is formed between C⁶ and C⁷, or: R^6a is methyl and R^6b and R⁷ are omitted, whereby a double bond is formed between C⁶ and C⁷, R¹⁵ and R¹⁶ are hydrogen, or together form methylene and R¹⁷ is selected from the group comprising hydrogen, C1-C4- alkyl and aIIyI. The derivatives also comprise the solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts of the aforementioned substances, with the proviso that certain compounds are excluded.