| 摘要 |
<p>A process for producing a leukocyte bank suitable for CAT therapy comprising the steps of providing a blood sample from a healthy donor individual selectively separating leukocytes from the sample; collecting the separated leukocytes in a holding vessel; transferring two or more aliquots of the separated leukocytes to independent double containment storage vessels, wherein each of the storage vessels contains, or is in fluid communication with, a cryopreservation medium; mixing each aliquot with the cryopreservation medium within each storage vessel; cryogenically preserving each of the two or more aliquots within each of the storage vessels, retrievably depositing each of the two or more storage vessels containing the aliquots of preserved leukocytes into two or more independent storage systems to produce a leukocyte bank which exhibits deposit redundancy, wherein steps are conducted within a closed or functionally closed system and are applied iteratively to a series of blood samples from different healthy donor individuals. The process further comprises digitally storing information obtained from each donor individual in a digital information unit so as to permit matching of leukocyte deposit and donor for later autologous transplantation.</p> |
