| 发明名称 |
Inhibitors of human tumor-expressed CCXCKR2 |
| 摘要 |
Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.
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| 申请公布号 |
US7649011(B2) |
申请公布日期 |
2010.01.19 |
| 申请号 |
US20030743281 |
申请日期 |
2003.12.22 |
| 申请人 |
CHEMOCENTRYX, INC. |
发明人 |
MELIKIAN ANITA;BURNS JENNIFER;MCMASTER BRIAN E.;SCHALL THOMAS;WRIGHT J. J. |
| 分类号 |
A61K31/541;A61K31/496;C07D207/06;C07D207/08;C07D207/09;C07D207/12;C07D207/14;C07D207/16;C07D211/14;C07D211/42;C07D211/56;C07D241/04;C07D241/42;C07D295/13;C07D401/04;C07D401/06;C07D405/04;C07D405/06;C07D405/12;C07D405/14;C07D417/02 |
主分类号 |
A61K31/541 |
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