1ALPHA-HYDROXY-2-METHYLENE-19-NOR-HOMOPREGNACALCIFEROL AND ITS THERAPEUTIC APPLICATIONS

摘要

This invention discloses 1.alpha.-hydroxy-2-methylene-19-nor- homopregnacalciferol and pharmaceutical uses therefor. This compound exhibit s pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte this evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis a s well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any calcemic activity and therefore may be used to treat immune disorders in humans as we ll as renal osteodystrophy.