| 摘要 |
<p>A SOFT, CHEWABLE CAPSULE FILM SUITABLE FOR MEDICAMENT OR FOODSTUFF ENCAPSULATION, AND A METHOD OF FABRICATING CAPSULES FROM SUCH A FILM. SUCH CAPSULES DEMONSTRATE FAST RUPTURE IN THE ORAL CAVITY, GOOD MOUTH FEEL AND CHEWABILITY, AND RAPID DISSOLUTION OF THE SHELL COMPONENTS. IN PARTICULAR, THE MODIFIED STARCH IS SUBSTANTIALLY UNGELATINIZED, DUE AT LEAST IN PART TO THE PROCESSING TEMPERATURE, AND MAY ACT AS A WATER RETENTION AGENT TO PROMOTE HYDRATION. ADDITIONALLY, GELATINS ARE SELECTED FOR BLOOM STRENGTHS THAT RESULT IN A ROBUST CAPSULES THAT MAY BE FABRICATED AT A THINNER WALL THICKNESS THAN PREVIOUSLY EXPERIENCED IN THE ART. ACCORDINGLY, SUCH THIN CAPSULES HAVE A SMALLER MASS THAN TRADITIONAL CAPSULES OF THE SAME SIZE AND DISSOLVE MORE QUICKLY THAN CHEWABLE CAPSULES HAVING GREATER THICKNESSES. THE CAPSULES MAY BE FABRICATED BY A ROTARY DIE PROCESS AT SPEEDS GREATER THAN THOSE GENERALLY KNOWN FOR SOFT CHEWABLE CAPSULES.</p> |
