发明名称 |
Modified Release Pharmaceutical Composition of Bupropion Hydrochloride |
摘要 |
A delayed extended release pharmaceutical composition includes a compressed core containing an effective amount of bupropion or its pharmaceutically acceptable salt, a water-attractant polymer. The core is preferably devoid of a stabilizer. The core is surrounded by an extended release layer, which is free of plasticizer and pore-forming agent. The extended release layer is surrounded by a delayed release layer. Alternating coats of extended release layer and delayed release layer may follow. A preferred extended release layer includes ethylcellulose and hydroxypropyl cellulose or hydroxypropyl methylcellulose and a preferred delayed release layer includes methacrylic acid copolymer and hydroxypropyl methylcellulose phthalate, lactose and a combination of triethyl citrate and polyethylene glycol and talc. A method of preparing the delayed extended release bupropion hydrochloride containing pharmaceutical composition is also disclosed.
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申请公布号 |
US2010008987(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
US20070438281 |
申请日期 |
2007.08.21 |
申请人 |
CHOWDARY PASULA BASAVAIAH;FANDA ANUJ KUMAR;MUKHERJI GOUR;PANCHAL MAULIK KIRITKUMAR;KANSAGRA PIYUSH KUMAR |
发明人 |
CHOWDARY PASULA BASAVAIAH;FANDA ANUJ KUMAR;MUKHERJI GOUR;PANCHAL MAULIK KIRITKUMAR;KANSAGRA PIYUSH KUMAR |
分类号 |
A61K9/24;A61K31/138 |
主分类号 |
A61K9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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