发明名称 |
PROCESS FOR THE PREPARATION OF PURE 4'-[4-METHYL-6-(1-METHYL-2-BENZIMIDAZOLYL)-2-PROPYL-1-BENZIMIDAZOLYL]METHYL]-2-BIPHENYLCARBOXYLIC ACID |
摘要 |
<p>The present invention relates to the purification of Telmisartan (I) from a mixture of water immiscible solvent and polar aprotic solvent, which results in the Telmisartan with the purity of above 99.5% by HPLC. Further, the precipitation process of the present invention improves flowability of crystallized product, ease of filtration from the crystalline medium, thereby increasing the yield, decreasing the cost and avoiding the drying problems.</p> |
申请公布号 |
WO2010004385(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
WO2009IB05934 |
申请日期 |
2009.06.15 |
申请人 |
AUROBINDO PHARMA LIMITED;KORRAPATI, VENKATA VARA PRASADA RAO;INTI, VENKATA SUBRAMANYESWARA RAO;ANANTA, RANI;MEENAKSHISUNDERAM, SIVAKUMARAN |
发明人 |
KORRAPATI, VENKATA VARA PRASADA RAO;INTI, VENKATA SUBRAMANYESWARA RAO;ANANTA, RANI;MEENAKSHISUNDERAM, SIVAKUMARAN |
分类号 |
C07D235/20;A61K31/4184;A61P9/00 |
主分类号 |
C07D235/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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