发明名称 |
Vgamma9Vdelta2 T cell proliferation agent, method for producing activated Vgamma9Vdelta2 T cells, and uses thereof |
摘要 |
A Vgamma9Vdelta2 T cell proliferation agent includes at least a bisphosphonate, interleukin 2, and interleukin 18. Since has properties that improve cell viability by inhibiting cell death, IL-18 is presumably capable of acting as a cofactor for the bisphosphonate so as to significantly increase the effect of Vgamma9Vdelta2 T cell proliferation by the bisphosphonate and the IL-2. This allows providing a Vgamma9Vdelta2 T cell proliferation agent capable of growing Vgamma9Vdelta2 T cells with a proliferated efficiency significantly high compared to conventional methods so that the proliferated Vgamma9Vdelta2 T cells have a high antitumor activity and high cytokine productivity.
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申请公布号 |
US2010009447(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
US20080316973 |
申请日期 |
2008.12.17 |
申请人 |
HYOGO COLLEGE OF MEDICINE |
发明人 |
OKAMURA HARUKI;KUBO SHUJI;LI WEN |
分类号 |
C12N5/00;C07F9/40;C07K14/54 |
主分类号 |
C12N5/00 |
代理机构 |
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地址 |
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