发明名称 |
Diagnostic and Therapeutic Target Adarb2 Proteins for Neurodegenerative Diseases |
摘要 |
The present invention discloses a dysregulation of the ADARB2 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides methods for diagnosing and prognosticating Alzheimer's disease in a subject, and for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating and preventing Alzheimer's disease and related neurodegenerative disorders using the ADARB2 gene and its corresponding gene products. Screening methods for modulating agents of neurodegenerative diseases are also disclosed. |
申请公布号 |
US2010008921(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
US20060922060 |
申请日期 |
2006.06.14 |
申请人 |
EVOTEC NEUROSCIENCES GMBH |
发明人 |
POHLNER JOHANNES;VON DER KAMMER HEINZ |
分类号 |
A61K39/395;A01K67/00;A61K31/7088;A61K38/16;C07H21/04;C07K14/00;C07K16/00;C12Q1/02;C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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