发明名称 |
NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF |
摘要 |
Means and methods for the diagnosis, characterization, prognosis and treatment of cancer, specifically targeting cancer stem cells are disclosed Provided is an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth, and a method of treating cancer comprising administering said antibody to a subject. |
申请公布号 |
CA2729602(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
CA20092729602 |
申请日期 |
2009.07.08 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, AUSTIN L.;HOEY, TIMOTHY CHARLES;BRUHNS, MAUREEN FITCH;AXELROD, FUMIKO TAKADA |
分类号 |
C07K16/28;A61K39/395;A61K47/48;A61P35/00;C12N5/16;C12N15/13 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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