NOTCH-BINDING AGENTS AND ANTAGONISTS AND METHODS OF USE THEREOF
摘要
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-hgand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-hgand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
申请公布号
CA2729306(A1)
申请公布日期
2010.01.14
申请号
CA20092729306
申请日期
2009.07.08
申请人
ONCOMED PHARMACEUTICALS, INC.
发明人
GURNEY, AUSTIN L.;HOEY, TIMOTHY CHARLES;HTUN VAN DER HORST, EDWARD THEIN;SATO, AARON KEN;LIU, YUAN CHING;BRUHNS, MAUREEN FITCH;LEWICKI, JOHN A.