发明名称 |
Alpha-galactosyl ceramide analogs and their use as immunotherapies |
摘要 |
The present disclosure relates to synthetic alpha-galactosyl ceramide (alpha-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula 1: or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.
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申请公布号 |
US2010008954(A1) |
申请公布日期 |
2010.01.14 |
申请号 |
US20080218082 |
申请日期 |
2008.07.11 |
申请人 |
WONG CHI-HUEY;YU ALICE;CHANG YA-JEN;LIN KUN-HSIEN;HUNG JUNG-TUNG |
发明人 |
WONG CHI-HUEY;YU ALICE;CHANG YA-JEN;LIN KUN-HSIEN;HUNG JUNG-TUNG |
分类号 |
A61K39/02;A61K31/7034;A61K39/00;C07H15/18 |
主分类号 |
A61K39/02 |
代理机构 |
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地址 |
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