发明名称 |
TGFP-CAP PEPTIDE AND ITS USES |
摘要 |
<p>The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.</p> |
申请公布号 |
EP2142572(A1) |
申请公布日期 |
2010.01.13 |
申请号 |
EP20070808197 |
申请日期 |
2007.09.12 |
申请人 |
CAREGEN CO., LTD. |
发明人 |
CHUNG, YONG JI;KIM, YOUNG DEUG;KIM, EUN MI;CHOI, JUN-YOUNG;KIM, JIN SEUK;SONG, SANG SU;CHO, KYOUNG MI |
分类号 |
C07K19/00;A61K8/18;A61K38/10;A61K38/17;C07K9/00 |
主分类号 |
C07K19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|