| 发明名称 |
3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
| 摘要 |
<p>The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.</p> |
| 申请公布号 |
EP2142535(A2) |
申请公布日期 |
2010.01.13 |
| 申请号 |
EP20080735532 |
申请日期 |
2008.03.27 |
| 申请人 |
NOVARTIS AG |
发明人 |
BOETTCHER, ANDREAS;BUSCHMANN, NICOLE;FURET, PASCAL;GROELL, JEAN-MARC;KALLEN, JOERG;HERGOVICH LISZTWAN, JOANNA;MASUYA, KEIICHI;MAYR, LORENZ;VAUPEL, ANDREA |
| 分类号 |
C07D403/04;A61K31/4164;A61P35/00 |
主分类号 |
C07D403/04 |
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